ABSTRACT
Hypertension is one of the leading causes of death and disability among adults all over the world and emerging health problem in India. Over 90% of patients with high blood pressure have Essential Hypertension. Alterations in the intracellular free Calcium regulation as well as disturbances of extracellular calcium homeostasis have been observed in patients with essential hypertension. AIM: To study the levels of serum Calcium in patients with primary hypertension and to correlate the serum Calcium levels with severity of disease. Methods: Information for the study was collected from patients admitted to BLDEDU’S Shri B.M Patil Medical college Hospital and Research center, Vijayapura from November 2016 to June 2018. Patients were screened and who met inclusion criteria where studied. Serum calcium was done in total 126 patient which were divided equally in 3 groups named Stage I Hypertensives, Stage II Hypertensives, and Controls or Normotensives, 42 patients in each groups and results were obtained and Comparative Study was done. Results: In our study mean age in hypertensive patients was 50.80 ± 19.38 and in controls it was 43.19 ± 19.171. There was no significant difference of serum calcium was obtained in relation to age in both the Stage of Hypertension. There was no significant difference in relation to gender. In total Hypertensives cases mean ± SD of S. Calcium was 8.408 ± 1.07 mg/dl while in normotensives cases it was 9.190 ± 0.7827 mg/dl. In all Stage I Hypertensive case mean ± SD of S. Calcium was 8.626 ± 0.6012 mg/dl (p = 0.032) while in Stage II Hypertensive it was 8.190 ± 1.3668 mg/dl (p = 0.0001). This results were significantly low than normotensives. But comparing both Stage of Hypertension mean was lower in stage II but it is not significantly low. So level of S. Calcium has inverse relation with Hypertension severity. Conclusion: In patients of Essential hypertension mean serum Calcium levels were found to be low in comparison to Normotensives. Further, Stage II Hypertensive patient has more reduced levels of serum calcium than Stage I, hence low Serum Calcium levels were associated as the severity of the disease increases.